The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats

Matti Mintz, Irit Gordon, Netta Roz, Moshe Rehavi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalBrain Research
Volume668
Issue number1-2
DOIs
StatePublished - 30 Dec 1994

Keywords

  • DA
  • DA transporter
  • DA uptake
  • Repeated amphetamine
  • Rotation
  • Sensitization
  • Striatum

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