TY - JOUR
T1 - The effect of radioiodine on eradication of Helicobacter pylori infection in patients with thyroid cancer-A pilot study
AU - Shmuely, Haim
AU - Friedman, Michael
AU - Aronov, Igor
AU - Bernstine, Hanna
AU - Yahav, Jacob
AU - Samra, Zmira
AU - Chodick, Gabriel
AU - Hamilton, Craig S.
AU - Samuelson, Christian G.
AU - Groshar, David
PY - 2012/9
Y1 - 2012/9
N2 - Recently, 32% of Helicobacter pylori (H pylori) infected patients who were treated for differentiated thyroid carcinoma (DTC) were found to have a negative urease breath test at 2 months posttreatment. Our objectives were to eradication of clarify equivocal findings, and determine whether radioiodine eradicates this chronicbacterial infection. Twenty-eight patients (25 DTC patients and 3 with hyperthyroidism) positive for H pylori stool antigen were treated with oral radioiodine (131I) at a dose of 100 to 200 mCi in 18 patients with thyroid carcinoma; 30 mCi in 1 patient with a significant residual mass in the thyroid bed after surgery; and 4 mCi in 6 patients who had been treated with 100 to 150 mCi over the last 5 years. The hyperthyroid patients received 10 to 20 mCi. To standardize the results, and better compare with a previous study, only those patients who received a dose of 100 to 200 mCi were included for analysis. All 18 DTC patients who tested positive for H pylori stool antigen before radioiodine treatment remained positive 3 months posttreatment, indicating an eradication rate of 0% with an upper 95% confidence limit of 18.53%. Radioiodine administered to H pylori infected patients did not eradicate infection in Israeli patients.
AB - Recently, 32% of Helicobacter pylori (H pylori) infected patients who were treated for differentiated thyroid carcinoma (DTC) were found to have a negative urease breath test at 2 months posttreatment. Our objectives were to eradication of clarify equivocal findings, and determine whether radioiodine eradicates this chronicbacterial infection. Twenty-eight patients (25 DTC patients and 3 with hyperthyroidism) positive for H pylori stool antigen were treated with oral radioiodine (131I) at a dose of 100 to 200 mCi in 18 patients with thyroid carcinoma; 30 mCi in 1 patient with a significant residual mass in the thyroid bed after surgery; and 4 mCi in 6 patients who had been treated with 100 to 150 mCi over the last 5 years. The hyperthyroid patients received 10 to 20 mCi. To standardize the results, and better compare with a previous study, only those patients who received a dose of 100 to 200 mCi were included for analysis. All 18 DTC patients who tested positive for H pylori stool antigen before radioiodine treatment remained positive 3 months posttreatment, indicating an eradication rate of 0% with an upper 95% confidence limit of 18.53%. Radioiodine administered to H pylori infected patients did not eradicate infection in Israeli patients.
KW - Differentiated thyroid carcinoma
KW - Eradication treatment
KW - Helicobacter pylori
KW - Hyperthyroidism
KW - Radioactive iodine
UR - http://www.scopus.com/inward/record.url?scp=84866018632&partnerID=8YFLogxK
U2 - 10.1016/j.otot.2012.03.001
DO - 10.1016/j.otot.2012.03.001
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AN - SCOPUS:84866018632
SN - 1043-1810
VL - 23
SP - 206
EP - 210
JO - Operative Techniques in Otolaryngology - Head and Neck Surgery
JF - Operative Techniques in Otolaryngology - Head and Neck Surgery
IS - 3
ER -
