The effect of psychostimulants on [3H]dopamine uptake and release in rat brain synaptic vesicles

K. Schwartz, Avraham Weizman, Moshe Rehavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Amphetamine and its derivatives are psychostimulants active at the plasma membrane monoamine transporters. In the present study we assessed the interaction of parachloroamphetamine, D-amphetamine, fenfluramine and methylendioxymethamphetamine with brain vesicular monoamine transporter using purified rat striatal synaptic vesicles. All four psychostimulants inhibited vesicular [3H]dopamine uptake in a competitive and dose-dependent manner and had no effect on [3H]dihydrotetrabenazine binding. At higher concentrations the drugs enhanced [3H]dopamine vesicular efflux. Parachloroamphetamine was the most potent agent while methylendioxymethamphetamine was the weakest one. The vesicular activities may be relevant to their neurotoxicity.

Original languageEnglish
Pages (from-to)1347-1352
Number of pages6
JournalJournal of Neural Transmission
Issue number9
StatePublished - Sep 2006


  • D-amphetamine
  • Fenfluramine
  • Methylendioxymethamphetamine
  • Neurotoxicity
  • Parachloroamphetamine
  • Psychostimulants
  • Vesicular Monoamine Transporter (VMAT2)


Dive into the research topics of 'The effect of psychostimulants on [3H]dopamine uptake and release in rat brain synaptic vesicles'. Together they form a unique fingerprint.

Cite this