The effect of prostatic factors on the release of interleukin-1 by human polymorphonuclear cells

Z. H. Marcus, L. Nebel, A. Lindner

Research output: Contribution to journalArticlepeer-review

Abstract

Extracts prepared from prostate glands (PrExt) obtained from patients undergoing surgery for benign prostatic hypertrophy (BPH) or prostatic carcinoma (CaP) were tested as possible inhibitors of an in vitro test for human blast transformation (BT). Thirty four of fifty (68%) PrExt samples caused 64-99% inhibition. An inhibitory effect of HuSePl and PrExt on interleukin 1 (IL-1) release from human polymorphic cells (PMN) was observed, using a mouse system test to determine IL-1 effect. Increasing concentrations of HuSeP1 and/or PrExt resulted in progressive inhibition of [3H]thymidine uptake. An inhibitory effect of HuSePl or PrExt on release of material from PMN that stimulates thymocyte proliferation was demonstrated. The unstimulated PMN supernatant showed little or no thymocyte-proliferative activity, whereas supernatant fluids from PMN stimulated with LPS or zymosan A increased the proliferating capacity. The presence of HuSePl (500 μg/ml) or of PrExt (500 μg/ml) along with LPS or zymosan A significantly suppressed the production of stimulating factor as demonstrated by decreased thymocyte proliferation.

Original languageEnglish
Pages (from-to)115-116
Number of pages2
JournalMedical Science Research
Volume17
Issue number2
StatePublished - 1989

Fingerprint

Dive into the research topics of 'The effect of prostatic factors on the release of interleukin-1 by human polymorphonuclear cells'. Together they form a unique fingerprint.

Cite this