Prostaglandins Al, A2, B2, E2 and F2α inhibit glycosaminoglycan sulphation in pig costal cartilage discs above O.1μmM (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 μg/ml (0.02 mM) prostaglandin E2 and F2α inhibited cartilage DNA synthesis.However at 100 ng/ml (10 μM) this inhibition was again observed.The basal production of prostaglandins E2 and F2α by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.
|Number of pages||8|
|Journal||Prostaglandins Leukotrienes and Essential Fatty Acids|
|State||Published - Feb 1980|