TY - JOUR
T1 - The effect of prostaglandins on sulphate and thymidine incorporation in pig cartilage
AU - Falconer, J.
AU - Dekel, S.
AU - Francis, M. J.O.
PY - 1980/2
Y1 - 1980/2
N2 - Prostaglandins Al, A2, B2, E2 and F2α inhibit glycosaminoglycan sulphation in pig costal cartilage discs above O.1μmM (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 μg/ml (0.02 mM) prostaglandin E2 and F2α inhibited cartilage DNA synthesis.However at 100 ng/ml (10 μM) this inhibition was again observed.The basal production of prostaglandins E2 and F2α by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.
AB - Prostaglandins Al, A2, B2, E2 and F2α inhibit glycosaminoglycan sulphation in pig costal cartilage discs above O.1μmM (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 μg/ml (0.02 mM) prostaglandin E2 and F2α inhibited cartilage DNA synthesis.However at 100 ng/ml (10 μM) this inhibition was again observed.The basal production of prostaglandins E2 and F2α by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.
UR - http://www.scopus.com/inward/record.url?scp=0018918948&partnerID=8YFLogxK
U2 - 10.1016/0161-4630(80)90039-7
DO - 10.1016/0161-4630(80)90039-7
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AN - SCOPUS:0018918948
SN - 0161-4630
VL - 4
SP - 87
EP - 94
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 2
ER -