The effect of prostaglandins on sulphate and thymidine incorporation in pig cartilage

J. Falconer, S. Dekel, M. J.O. Francis

Research output: Contribution to journalArticlepeer-review

Abstract

Prostaglandins Al, A2, B2, E2 and F2α inhibit glycosaminoglycan sulphation in pig costal cartilage discs above O.1μmM (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 μg/ml (0.02 mM) prostaglandin E2 and F2α inhibited cartilage DNA synthesis.However at 100 ng/ml (10 μM) this inhibition was again observed.The basal production of prostaglandins E2 and F2α by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.

Original languageEnglish
Pages (from-to)87-94
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume4
Issue number2
DOIs
StatePublished - Feb 1980
Externally publishedYes

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