TY - JOUR
T1 - The effect of pH on platelet and coagulation factor activities
AU - Chaimoff, Chaim
AU - Creter, Draga
AU - Djaldetti, Meir
PY - 1978/8
Y1 - 1978/8
N2 - After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosis induces platelet aggregation, platelet calcium and serotonin release, as well as platelet factor III availability. The prothrombin and partial thromboplastin times approached normal levels, whereas the fibrinogen level did not change significantly. The results obtained may serve as an explanation for the control of the intragastric bleeding in patients treated by maintenance of their gastric pH at 7.0.
AB - After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosis induces platelet aggregation, platelet calcium and serotonin release, as well as platelet factor III availability. The prothrombin and partial thromboplastin times approached normal levels, whereas the fibrinogen level did not change significantly. The results obtained may serve as an explanation for the control of the intragastric bleeding in patients treated by maintenance of their gastric pH at 7.0.
UR - http://www.scopus.com/inward/record.url?scp=0018148943&partnerID=8YFLogxK
U2 - 10.1016/0002-9610(78)90241-6
DO - 10.1016/0002-9610(78)90241-6
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C2 - 28678
AN - SCOPUS:0018148943
SN - 0002-9610
VL - 136
SP - 257
EP - 259
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 2
ER -