The effect of open heart surgery on tuberculin skin test reactivity

Michal Stein, Batia Sela-Razon, Ilan Linder, Eli Somekh*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


To examine whether treatment with cardiopulmonary bypass (CPB), which causes transient cellular immunity depression, influences tuberculin skin testing (TST) interpretation. The study was also aimed to assess the degree of cellular immunity depression following open heart surgery. Fifteen children from developing countries with latent tuberculosis (TST ≥10 mm), undergoing open heart surgery had their TST repeated within 48-72 h following surgery. We compared the size of skin test induration before and after surgery and the relation of postsurgery skin induration to time on CPB (pump time). There was no significant difference in the size of induration before and after surgery (mean: 14.7 mm versus 13 mm, respectively). Pump time ranged from 38 to 204 min (mean: 110 min). Two of the children had pump time over 3 h. The TST of both of them turned negative after surgery, as opposed to all other children (P = 0.01). Most patients retained skin test reactivity. Only patients with pump time longer than 3 h had a negative TST.

Original languageEnglish
Title of host publicationAutoimmunity, Part A Basic Principles and New Diagnostic Tools
PublisherBlackwell Publishing Inc.
Number of pages6
ISBN (Print)1573316636, 9781573316637
StatePublished - Aug 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Open heart surgery
  • Skin test
  • Tuberculin


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