The effect of NIMA matching in adult unrelated mismatched hematopoietic stem cell transplantation – a joint study of the Acute Leukemia Working Party of the EBMT and the CIBMTR

Julia Pingel, Tao Wang, Yvonne Hagenlocher, Camila J. Hernández-Frederick, Arnon Nagler, Michael D. Haagenson, Katharina Fleischhauer, Katharine C. Hsu, Michael R. Verneris, Stephanie J. Lee, Mohamad Mohty, Emmanuelle Polge, Stephen R. Spellman*, Alexander H. Schmidt, Jon J. van Rood

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Hematological malignancies can be cured by unrelated donor allogeneic HSCT and outcomes are optimized by high-resolution HLA matching at HLA-A, -B, -C, -DRB1 and -DQB1 (10/10 match). If a 10/10 match is unavailable, 9/10 matches may be suitable. Fetal exposure to non-inherited maternal antigens (NIMA) may impart lifelong NIMA tolerance modulating the immune response, as shown in adult haploidentical transplantation. In cord blood transplantation, NIMA matching lowered rates of aGvHD and TRM; in haploidentical transplantation, sibling donors with non-shared maternal antigens showed less grade II-IV aGvHD. This retrospective analysis examined if 9/10 matched unrelated donor HSCT benefits from NIMA matching. DKMS contacted 1,735 donors and obtained 733 (42%) maternal samples. NIMA-matched and -mismatched cases with a minimum follow-up of 1 year were compared by univariate and multivariate analyses adjusted for co-variates for OS, DFS, relapse, TRM and a/cGvHD. The study population (N = 445) comprised 31 NIMA-matched and 414 NIMA-mismatched cases. No significant differences between NIMA-matched and NIMA-mismatched groups were found for any outcomes with similar OS and TRM rates within both groups. This study provides the proof of principle that NIMA matching is possible in the unrelated donor HSCT setting; larger studies may be able to provide significant results.

Original languageEnglish
Pages (from-to)849-857
Number of pages9
JournalBone Marrow Transplantation
Volume54
Issue number6
DOIs
StatePublished - 1 Jun 2019
Externally publishedYes

Funding

FundersFunder number
Actinium Pharmaceuticals, Inc.
Amgen, Inc.
Amneal Biosciences
Angiocrine Bioscience, Inc.
HRSA/DHHS
Office of Naval ResearchN00014-17-1-2388, N0014-17-1-2850
National Heart, Lung, and Blood InstituteU10HL069294
National Cancer Institute5U24CA076518
National Institute of Allergy and Infectious Diseases
Health Resources and Services AdministrationHHSH250201200016C
University of Minnesota

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