The effect of mode of conception on obstetrical outcomes differs by body mass index

Ronit Machtinger, Chloe Zera, Catherine Racowsky, Stacey Missmer, Antonio Gargiulo, Eyal Schiff, Louise Wilkins-Haug*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study compared the odds of adverse obstetrical outcomes of pregnancies in women who conceived from IVF (n = 464) versus spontaneous conception (n = 1171) after stratification into three body mass index (BMI) groups: normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) and obese (>30 kg/m2). With increasing BMI, incidences of complications between IVF and spontaneously conceived groups narrowed. Among women with normal BMI, IVF pregnancies were associated with increased odds of placental ischaemic disorders (11.3% versus 7.0%, adjusted odds ratio [aOR] = 2.24; 95% confidence interval [CI] = 1.25-4.04) and low birthweight <2500 g (10.6% versus 8.0%, aOR = 2.08; 95% CI = 1.12-3.88). Among overweight women, only low birthweight (<2500 g) was significantly increased (15.6% versus 6.2%, aOR = 4.33; 95%, CI = 1.61-11.63). For obese women, there were no differences between IVF and spontaneously conceived pregnancies for either placental ischaemic disorders (12.5 versus 20.2%, OR = 0.43, 95% CI = 0.17-1.1) or low birthweight (10.0% versus 11.0%, aOR = 0.7, 95% CI = 0.24-2.08). Overall, the odds of adverse obstetrical outcomes were not significantly greater in IVF singleton pregnancies compared with those conceived spontaneously as BMI increased.

Original languageEnglish
Article number1392
Pages (from-to)531-537
Number of pages7
JournalReproductive BioMedicine Online
Volume31
Issue number4
DOIs
StatePublished - Oct 2015

Keywords

  • BMI
  • IVF pregnancy
  • obesity
  • spontaneous pregnancy

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