The effect of maternal sleep-disordered breathing on the infant's neurodevelopment

Riva Tauman*, Luba Zuk, Shimrit Uliel-Sibony, Jessica Ascher-Landsberg, Shlomit Katsav, Mira Farber, Yakov Sivan, Haim Bassan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Objective We sought to examine the effect of maternal sleep-disordered breathing (SDB) on infant general movements (GMs) and neurodevelopment. Study Design Pregnant women with uncomplicated full-term pregnancies and their offspring were prospectively recruited from a community and hospital low-risk obstetric surveillance. All participants completed a sleep questionnaire on second trimester and underwent ambulatory sleep evaluation (WatchPAT; Itamar Medical, Caesarea, Israel). They were categorized as SDB (apnea hypopnea index >5) and controls. Infant GMs were assessed in the first 48 hours and at 8-11 and 14-16 weeks of age. At 12 months of age the Infant Developmental Inventory and the Brief Infant Sleep Questionnaire were administered. Results In all, 74 women and their full-term infants were studied. Eighteen (24%) women had SDB. Mean birthweight was 3347.1 ± 423.9 g. Median Apgar score at 5 minutes was 10 (range, 8-10). In adjusted comparisons, no differences were found between infants born to mothers with SDB and controls in GM scores in all 3 evaluations. Low social developmental score was detected at 12 months in 64% of infants born to SDB mothers compared to 25% of infants born to controls (adjusted P =.036; odds ratio, 16.7). Infant snoring was reported by 41.7% of mothers with SDB compared to 7.5% of controls (P =.004). Conclusion Our preliminary results suggest that maternal SDB during pregnancy has no adverse effect on neonatal and infant neuromotor development but may affect social development at 1 year.

Original languageEnglish
Pages (from-to)656.e1-656.e7
JournalAmerican Journal of Obstetrics and Gynecology
Volume212
Issue number5
DOIs
StatePublished - 1 May 2015

Funding

FundersFunder number
Israel Science Foundation

    Keywords

    • breathing
    • fetal outcome
    • neurodevelopment pregnancy
    • sleep-disordered

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