TY - JOUR
T1 - The effect of low-dose aspirin treatment on biochemical markers in pregnant hypertensive patients
AU - Bar, J.
AU - Rabinerson, D.
AU - Padoa, A.
AU - Nitzan, Z.
AU - Neri, A.
AU - Fisch, B.
AU - Hod, M.
PY - 1997
Y1 - 1997
N2 - We evaluated the known metabolic effects of aspirin in pregnant hypertensive patients. Eighty-seven pregnant women (12th-24th gestational week) were randomly allocated to low-dose aspirin or placebo treatment. Between the 24th28th gestational week the following tests were performed: oral glucose tolerance test, venous blood pH and base excess, coagulation profile, platelet count, morning (8 a.m.) cortisol, creatinine clearance and serum uric acid. A significantly higher serum uric acid level was detected in the low-dose aspirin group (5.6 ± 2.2 mg/dl) compared with the placebo group (4.7 ± 1.2 mg/dl, p = 0.048). No other significant difference was found for any of the other parameters tested. We conclude that low-dose aspirin treatment during the second half of pregnancy in hypertensive patients seems safe in terms of its effect on various maternal metabolic effects.
AB - We evaluated the known metabolic effects of aspirin in pregnant hypertensive patients. Eighty-seven pregnant women (12th-24th gestational week) were randomly allocated to low-dose aspirin or placebo treatment. Between the 24th28th gestational week the following tests were performed: oral glucose tolerance test, venous blood pH and base excess, coagulation profile, platelet count, morning (8 a.m.) cortisol, creatinine clearance and serum uric acid. A significantly higher serum uric acid level was detected in the low-dose aspirin group (5.6 ± 2.2 mg/dl) compared with the placebo group (4.7 ± 1.2 mg/dl, p = 0.048). No other significant difference was found for any of the other parameters tested. We conclude that low-dose aspirin treatment during the second half of pregnancy in hypertensive patients seems safe in terms of its effect on various maternal metabolic effects.
KW - Adverse effects
KW - Aspirin
KW - Hypertension
KW - Low-dose
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0031419015&partnerID=8YFLogxK
U2 - 10.3233/jrs-1997-10404
DO - 10.3233/jrs-1997-10404
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AN - SCOPUS:0031419015
SN - 0924-6479
VL - 10
SP - 249
EP - 254
JO - International Journal of Risk and Safety in Medicine
JF - International Journal of Risk and Safety in Medicine
IS - 4
ER -