The effect of low-dose aspirin treatment on biochemical markers in pregnant hypertensive patients

J. Bar*, D. Rabinerson, A. Padoa, Z. Nitzan, A. Neri, B. Fisch, M. Hod

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the known metabolic effects of aspirin in pregnant hypertensive patients. Eighty-seven pregnant women (12th-24th gestational week) were randomly allocated to low-dose aspirin or placebo treatment. Between the 24th28th gestational week the following tests were performed: oral glucose tolerance test, venous blood pH and base excess, coagulation profile, platelet count, morning (8 a.m.) cortisol, creatinine clearance and serum uric acid. A significantly higher serum uric acid level was detected in the low-dose aspirin group (5.6 ± 2.2 mg/dl) compared with the placebo group (4.7 ± 1.2 mg/dl, p = 0.048). No other significant difference was found for any of the other parameters tested. We conclude that low-dose aspirin treatment during the second half of pregnancy in hypertensive patients seems safe in terms of its effect on various maternal metabolic effects.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalInternational Journal of Risk and Safety in Medicine
Volume10
Issue number4
DOIs
StatePublished - 1997

Keywords

  • Adverse effects
  • Aspirin
  • Hypertension
  • Low-dose
  • Pregnancy

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