The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation

Ioan V. Matei, Irit Meivar-Levy, Daniela Lixandru, Simona DIma, Ioana R. Florea, Veronica M. Ilie, Radu Albulescu, Irinel Popescu, Sarah Ferber

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.

Original languageEnglish
Pages (from-to)19-31
Number of pages13
JournalRegenerative Medicine
Volume16
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • adult cell reprogramming
  • cell replacement therapy
  • diabetes
  • liver
  • pancreatic transcription factors
  • transdifferentiation

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