TY - JOUR
T1 - The effect of interferon on mouse myocardial capillaries
T2 - An ultrastructural study
AU - Salman, Hertzel
AU - Bergman, Michael
AU - Bessler, Hanna
AU - Alexandrova, Svetlana
AU - Djaldetti, Meir
PY - 1999/3/15
Y1 - 1999/3/15
N2 - BACKGROUND. Cardiotoxicity, including ischemia and myocardial infarction, is one of the complications observed after treatment with interferon (IFN). Therefore, the question has been raised whether IFN may cause damage to the small myocardial blood vessels. METHODS. In this study, 400 U of IFN-α-2b per g of body weight were injected intraperitoneally into 2 groups of C57 BI mice, 5 days a week for 3 and 5 months, respectively. Thin sections of the myocardium were examined with a transmission electron microscope and the ultrastructure of the capillaries was compared with that of control animals. RESULTS. The results showed a statistically significant increase in the thickness of the endothelial processes of the myocardial capillary walls in the mice treated with IFN, with a subsequent decrease in the size of the capillary lumen. The entire capillary area was not affected. CONCLUSIONS. These findings may serve as an additional explanation for the cardiac complications observed in patients treated with IFN.
AB - BACKGROUND. Cardiotoxicity, including ischemia and myocardial infarction, is one of the complications observed after treatment with interferon (IFN). Therefore, the question has been raised whether IFN may cause damage to the small myocardial blood vessels. METHODS. In this study, 400 U of IFN-α-2b per g of body weight were injected intraperitoneally into 2 groups of C57 BI mice, 5 days a week for 3 and 5 months, respectively. Thin sections of the myocardium were examined with a transmission electron microscope and the ultrastructure of the capillaries was compared with that of control animals. RESULTS. The results showed a statistically significant increase in the thickness of the endothelial processes of the myocardial capillary walls in the mice treated with IFN, with a subsequent decrease in the size of the capillary lumen. The entire capillary area was not affected. CONCLUSIONS. These findings may serve as an additional explanation for the cardiac complications observed in patients treated with IFN.
KW - Capillaries
KW - Electron microscopy
KW - Interferon
KW - Mouse myocardium
KW - Ultrastructure
UR - http://www.scopus.com/inward/record.url?scp=0033559659&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0142(19990315)85:6<1375::AID-CNCR22>3.0.CO;2-D
DO - 10.1002/(SICI)1097-0142(19990315)85:6<1375::AID-CNCR22>3.0.CO;2-D
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AN - SCOPUS:0033559659
SN - 0008-543X
VL - 85
SP - 1375
EP - 1379
JO - Cancer
JF - Cancer
IS - 6
ER -