The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: A double blind placebo-controlled pilot study

Tanya Gurevich, Chava Peretz, Orna Moore, Nina Weizmann, Nir Giladi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients. Method: BTX-A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6-month follow-up). Results: Eleven age- and disease severity-matched PD patients with disabling FOG participated. Six patients received BTX-A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination. Conclusion: BTX-A injections to the legs did not improve FOG and might increase fall risk.

Original languageEnglish
Pages (from-to)880-883
Number of pages4
JournalMovement Disorders
Volume22
Issue number6
DOIs
StatePublished - 30 Apr 2007

Keywords

  • Botulinum toxin
  • Falls
  • Freezing of gait
  • Parkinson's disease

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