TY - JOUR
T1 - The effect of histamine receptor antagonists on specific and nonspecific suppression of experimental contact sensitivity
AU - Mekori, Yoseph A.
AU - Bender, Edward M.
AU - Zapata-Sirvent, Ramon
AU - Hansbrough, John F.
AU - Claman, Henry N.
N1 - Funding Information:
From the Division of Clinical Immunology, Departments of Med-icine and Surgery, University of Colorado School of Medicine, Denver, Cola. Suported in part by Public Health Service grant 5 ROl AI-12685 from the National Institutes of Health. Received for publication June 20, 1984. Accepted for publication Nov. 6, 1984. Reprint requests: Henry N. Claman, M.D., Division of Clinical Immunology (B-164), University of Colorado School of Medi-cine, 4200 E. Ninth Ave., Denver, CO 80262. *Present address: Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215.
PY - 1985/7
Y1 - 1985/7
N2 - We studied the effects of H1 and H2 histamine receptor antagonists on down regulation of contact sensitivity (CS) to dinitrofluorobenzene (DNFB). Two H2 receptor antagonists, cimetidine and ranitidine, reversed the nonspecific immunosuppression of CS induced by burns. On the other hand, these two drugs did not affect the antigen-specific suppressor T cell-mediated tolerance to DNFB induced by dinitrobenzene sulfonic acid. Two H1 antagonists did not affect the down regulation of CS induced by either tolerance or burning. The differential sensitivities to histamine2-receptor antagonists indicate that the mechanisms for nonspecific burn-induced immunosuppression are different from those for hapten-specific tolerance to DNFB.
AB - We studied the effects of H1 and H2 histamine receptor antagonists on down regulation of contact sensitivity (CS) to dinitrofluorobenzene (DNFB). Two H2 receptor antagonists, cimetidine and ranitidine, reversed the nonspecific immunosuppression of CS induced by burns. On the other hand, these two drugs did not affect the antigen-specific suppressor T cell-mediated tolerance to DNFB induced by dinitrobenzene sulfonic acid. Two H1 antagonists did not affect the down regulation of CS induced by either tolerance or burning. The differential sensitivities to histamine2-receptor antagonists indicate that the mechanisms for nonspecific burn-induced immunosuppression are different from those for hapten-specific tolerance to DNFB.
UR - http://www.scopus.com/inward/record.url?scp=0021933047&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(85)90809-7
DO - 10.1016/0091-6749(85)90809-7
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AN - SCOPUS:0021933047
SN - 0091-6749
VL - 76
SP - 90
EP - 96
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -