The effect of heat treatment on glucose metabolism in human kidney cell line

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Abstract

The effect of supraoptimal temperature on various glucose metabolism pathways of human kidney cell line was studied. Exposure of cells to 44° C for longer than one hour resulted in decreased activity of the tri-carboxylic-acid (Krebs) cycle, which hardly recovered at 72 hours. The first few steps of the pentose phosphate pathway were found to be much less sensitive to heat treatment than the whole cycle, and continued to be partially active even after a 3-hour exposure to 48°C.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume18
Issue number1
DOIs
StatePublished - Dec 1975

Keywords

  • Glucose metabolism
  • Heat effect
  • Human kidney cell line

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