TY - JOUR
T1 - The effect of gluten-free diet on cardiovascular risk factors in newly diagnosed pediatric celiac disease patients
AU - Zifman, Eyal
AU - Waisbourd-Zinman, Orith
AU - Marderfeld, Luba
AU - Zevit, Noam
AU - Guz-Mark, Anat
AU - Silbermintz, Ari
AU - Assa, Amit
AU - Mozer-Glassberg, Yael
AU - Biran, Neta
AU - Reznik, Dana
AU - Poraz, Irit
AU - Shamir, Raanan
N1 - Publisher Copyright:
© 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Objectives:Although gluten-free diet (GFD) is the only proven therapy for celiac disease (CD), its effect on cardiovascular disease (CVD) risk factors is still unclear. Our aim was to determine whether adherence to GFD affects CVD risk factors among newly diagnosed pediatric CD subjects.Methods:We prospectively enrolled pediatric subjects undergoing upper gastrointestinal endoscopy for suspected CD. We collected anthropometric and laboratory parameters related to CVD risk factors at the time of CD diagnosis and 1 year after initiation of a GFD and evaluated changes in CVD risk factors. Paired t tests or Wilcoxon nonparametric tests were used, each when appropriate.Results:One hundred ten newly diagnosed CD pediatric subjects were included in the analysis. There were 64 (58.2%) girls and the mean age at diagnosis was 6.8±3.4 years. Median body mass index z scores (P=0.84), rates of underweight or overweight (P=0.32), and rates of elevated blood pressure (P=0.78) remained unchanged. Although median fasting insulin levels increased (1.9 vs 5.4μU/mL, P<0.001), insulin resistance as measured by homeostatic model assessment did not increase after 1 year of GFD (P=0.16). Although rates of dyslipidemia remained unchanged, median high-density lipoprotein levels increased on GFD (47 vs 51mg/dL, P<0.001).Conclusions:In this pediatric CD cohort, GFD for 1 year was not associated with increased CVD risk factors. The long-Term significance of these mild changes is yet to be determined.
AB - Objectives:Although gluten-free diet (GFD) is the only proven therapy for celiac disease (CD), its effect on cardiovascular disease (CVD) risk factors is still unclear. Our aim was to determine whether adherence to GFD affects CVD risk factors among newly diagnosed pediatric CD subjects.Methods:We prospectively enrolled pediatric subjects undergoing upper gastrointestinal endoscopy for suspected CD. We collected anthropometric and laboratory parameters related to CVD risk factors at the time of CD diagnosis and 1 year after initiation of a GFD and evaluated changes in CVD risk factors. Paired t tests or Wilcoxon nonparametric tests were used, each when appropriate.Results:One hundred ten newly diagnosed CD pediatric subjects were included in the analysis. There were 64 (58.2%) girls and the mean age at diagnosis was 6.8±3.4 years. Median body mass index z scores (P=0.84), rates of underweight or overweight (P=0.32), and rates of elevated blood pressure (P=0.78) remained unchanged. Although median fasting insulin levels increased (1.9 vs 5.4μU/mL, P<0.001), insulin resistance as measured by homeostatic model assessment did not increase after 1 year of GFD (P=0.16). Although rates of dyslipidemia remained unchanged, median high-density lipoprotein levels increased on GFD (47 vs 51mg/dL, P<0.001).Conclusions:In this pediatric CD cohort, GFD for 1 year was not associated with increased CVD risk factors. The long-Term significance of these mild changes is yet to be determined.
KW - body mass index
KW - dyslipidemia
KW - hypertension
KW - insulin
UR - http://www.scopus.com/inward/record.url?scp=85060612793&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000002235
DO - 10.1097/MPG.0000000000002235
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C2 - 30562306
AN - SCOPUS:85060612793
SN - 0277-2116
VL - 68
SP - 684
EP - 688
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 5
ER -