The effect of gestational diabetes mellitus on human milk macronutrients content

Dana Shapira, Dror Mandel*, Francis B. Mimouni, Hadar Moran-Lev, Ronella Marom, Laurence Mangel, Ronit Lubetzky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To test the null hypothesis that human milk (HM) macronutrients (fat, lactose, protein) and caloric content in women with gestational diabetes mellitus (GDM) is similar to that of women without GDM. Study design: Sixty-two lactating mothers (31 GDM, 31 no-GDM) were studied after confirmation by 100-g oral glucose tolerance test. Each mother contributed three manually expressed HM samples (within 72 h after labor (colostrum), after 7 days (transitional) and at 14 days (mature)). Analysis was done by infrared transmission spectroscopy. Results: Non-GDM and GDM groups did not differ by maternal age, pre-pregnancy weight, height, diet, pregnancy weight gain, gestational age, and infant birth weight. Macronutrients content in colostrum and transitional milk did not differ between groups. Fat and energy contents in mature HM were higher in non-GDM samples than in GDM samples (p = 0.07 and p < 0.02, respectively). Conclusion: Fat and energy content of mature HM obtained from mothers with GDM is lower compared to that of mature HM from mothers without GDM.

Original languageEnglish
Pages (from-to)820-823
Number of pages4
JournalJournal of Perinatology
Issue number6
StatePublished - 1 Jun 2019


Dive into the research topics of 'The effect of gestational diabetes mellitus on human milk macronutrients content'. Together they form a unique fingerprint.

Cite this