The effect of geometry on tumor thermal profile and its use in tumor functional state estimation

Michal Tepper*, Asaf Shoval, Israel Gannot

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Thermal differences between transplanted tumors and tumors in humans prevent the implementation of thermographic methods developed in mice models to human models and vise-versa. Transplantable tumors tend to have an extruding shape, which may affect the thermal patterns. This hypothesis was studied in phantom experiments and simulations. A correlation between tumor dimensions and relative temperature was found and used to estimate tumor functional state from previously published in vivo experiments. A correlation was found between temperature differences and tumor growth rates (tumor aggressiveness) and the effect of tumor treatment was demonstrated, showing the potential for in vivo, non-invasive tumor monitoring.

Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalJournal of Biophotonics
Volume8
Issue number3
DOIs
StatePublished - 1 Mar 2015

Keywords

  • Cancer
  • Temperature mapping
  • Tumor thermometry
  • Xenografts

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