The effect of food and exercise on the skin response to compound 48 80 in patients with food-associated exercise-induced urticaria-angioedema

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Abstract

Food-associated, exercise-induced urticaria-angioedema is increasingly being recognized. We studied five atopic individuals in whom ingestion of food was followed by exercise-induced urticaria-angioedema. The combined effect of food and exercise on skin wheal response to compound 48 80 and histamine was studied. Symptoms could be reproduced in only four of the patients who performed strenuous exercise after ingestion of food to which they were skin sensitive. When symptoms appeared, that is, after a combination of food and exercise challenge, there was a marked increase in the wheal response to compound 48 80 (>200%) and not to histamine. Food or exercise challenge alone did not induce any significant change in the skin reactivity to compound 48 80 or to histamine. It was concluded that mast cell releasability could be increased when the patient was subjected to combined factors.

Original languageEnglish
Pages (from-to)1155-1158
Number of pages4
JournalJournal of Allergy and Clinical Immunology
Volume81
Issue number6
DOIs
StatePublished - Jun 1988

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