@article{64f08eece64649c280ff8bf2a2db6ead,
title = "The effect of electrostatic shielding on H tunneling in R67 dihydrofolate reductase",
abstract = "(Figure Presented) The nature of the C-H→C transfer catalyzed by the primitive plasmidal enzyme R67 dihydrofolate reductase was examined as function of the ionic strength of the medium. Kinetic isotope effects and theoretical calculations suggested that, at high ionic strength, electrostatic repulsion between the H donor and H acceptor is reduced, and the reaction coordinate is better organized for H tunneling.",
keywords = "Dihydrofolate reductase, Ionic strength, Isotope effects, Marcus theory, Tunneling",
author = "Atsushi Yahashiri and Guy Nimrod and Nir Ben-Tal and Howell, {Elizabeth E.} and Amnon Kohen",
year = "2009",
month = nov,
day = "2",
doi = "10.1002/cbic.200900451",
language = "אנגלית",
volume = "10",
pages = "2620--2623",
journal = "ChemBioChem",
issn = "1439-4227",
publisher = "Wiley-VCH Verlag",
number = "16",
}