The effect of dopamine on the pupillary diameter in mice

Amos D. Korczyn*, Ora Keren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Dopamine and adrenaline injected into mice produce dose-related mydriasis. The effects of both dopamine and adrenaline are antagonized similarly by the alpha-adrenergic blocking agents, phentolamine and thymoxamine, as well as by haloperidol, but are not prevented by pretreatment with reserpine. These results suggest that in mice dopamine produces mydriasis by direct stimulation of alpha-adrenergic receptors in the dilator iridis.

Original languageEnglish
Pages (from-to)757-763
Number of pages7
JournalLife Sciences
Issue number10
StatePublished - 10 Mar 1980


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