The effect of dopamine on the pupillary diameter in mice

Amos D. Korczyn; Ora Keren

doi:10.1016/0024-3205(80)90280-5

The effect of dopamine on the pupillary diameter in mice

Amos D. Korczyn^*, Ora Keren

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

Dopamine and adrenaline injected into mice produce dose-related mydriasis. The effects of both dopamine and adrenaline are antagonized similarly by the alpha-adrenergic blocking agents, phentolamine and thymoxamine, as well as by haloperidol, but are not prevented by pretreatment with reserpine. These results suggest that in mice dopamine produces mydriasis by direct stimulation of alpha-adrenergic receptors in the dilator iridis.

Original language	English
Pages (from-to)	757-763
Number of pages	7
Journal	Life Sciences
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(80)90280-5
State	Published - 10 Mar 1980

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title = "The effect of dopamine on the pupillary diameter in mice",

abstract = "Dopamine and adrenaline injected into mice produce dose-related mydriasis. The effects of both dopamine and adrenaline are antagonized similarly by the alpha-adrenergic blocking agents, phentolamine and thymoxamine, as well as by haloperidol, but are not prevented by pretreatment with reserpine. These results suggest that in mice dopamine produces mydriasis by direct stimulation of alpha-adrenergic receptors in the dilator iridis.",

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AB - Dopamine and adrenaline injected into mice produce dose-related mydriasis. The effects of both dopamine and adrenaline are antagonized similarly by the alpha-adrenergic blocking agents, phentolamine and thymoxamine, as well as by haloperidol, but are not prevented by pretreatment with reserpine. These results suggest that in mice dopamine produces mydriasis by direct stimulation of alpha-adrenergic receptors in the dilator iridis.

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The effect of dopamine on the pupillary diameter in mice

Abstract

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