TY - JOUR
T1 - The effect of dentin on the pulp tissue dissolution capacity of sodium hypochlorite and calcium hydroxide
AU - Slutzky-Goldberg, Iris
AU - Hanut, Aiham
AU - Matalon, Shlomo
AU - Baev, Valery
AU - Slutzky, Hagay
PY - 2013/8
Y1 - 2013/8
N2 - Introduction: Sodium hypochlorite (NaOCl) and calcium hydroxide (Ca[OH]2) have tissue dissolution capacity. The aim of this study was to evaluate the potential effect of dentin on their tissue dissolution capacity in a novel dentin model. Methods: Dentin models were prepared from 25 freshly extracted human molar teeth; the crowns were separated from the roots, and a rectangular inner shape was prepared. Pulp tissue samples adjusted to similar weights of 6.5 ± 0.2 mg were randomly divided into 6 groups: NaOCl groups in test tubes or dentin models for 1 hour, Ca(OH)2 groups in test tubes or dentin models for 1 week, and control groups saline in test tubes or dentin models for 1 week. The final weights after the experimental period were checked and compared with the initial weights. The differences were statistically analyzed. Results: The tissue dissolution capacity of Ca(OH) 2 was affected by the presence of dentin. Similarly, NaOCl lost its effect on the pulp tissue after incubation in dentin. Comparison between all test groups showed highly significant differences (P <.001). Conclusions: Dentin has a detrimental effect on the ability of NaOCl and Ca(OH)2 to dissolve pulp tissue. The dentin model appears to be an efficient tool for the study of interactions between local endodontic medicaments, dentin, and pulp tissue.
AB - Introduction: Sodium hypochlorite (NaOCl) and calcium hydroxide (Ca[OH]2) have tissue dissolution capacity. The aim of this study was to evaluate the potential effect of dentin on their tissue dissolution capacity in a novel dentin model. Methods: Dentin models were prepared from 25 freshly extracted human molar teeth; the crowns were separated from the roots, and a rectangular inner shape was prepared. Pulp tissue samples adjusted to similar weights of 6.5 ± 0.2 mg were randomly divided into 6 groups: NaOCl groups in test tubes or dentin models for 1 hour, Ca(OH)2 groups in test tubes or dentin models for 1 week, and control groups saline in test tubes or dentin models for 1 week. The final weights after the experimental period were checked and compared with the initial weights. The differences were statistically analyzed. Results: The tissue dissolution capacity of Ca(OH) 2 was affected by the presence of dentin. Similarly, NaOCl lost its effect on the pulp tissue after incubation in dentin. Comparison between all test groups showed highly significant differences (P <.001). Conclusions: Dentin has a detrimental effect on the ability of NaOCl and Ca(OH)2 to dissolve pulp tissue. The dentin model appears to be an efficient tool for the study of interactions between local endodontic medicaments, dentin, and pulp tissue.
KW - Calcium hydroxide
KW - dentin
KW - dissolution
KW - pulp tissue
KW - sodium hypochlorite
UR - http://www.scopus.com/inward/record.url?scp=84880705419&partnerID=8YFLogxK
U2 - 10.1016/j.joen.2013.04.040
DO - 10.1016/j.joen.2013.04.040
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C2 - 23880263
AN - SCOPUS:84880705419
SN - 0099-2399
VL - 39
SP - 980
EP - 983
JO - Journal of Endodontics
JF - Journal of Endodontics
IS - 8
ER -