Abstract
Interaction between pokeweed mitogen stimulated secondary lymphocytes (PWM lymphocytes) and target fibroblasts resulted in over 80% adherence of the sensitized lymphocytes to the target cells. Adherence is by pseudopod penetration into target fibroblasts. The only lymphocyte cellular components found in the contact region were microfilaments. Cytochalasin B completely inhibited the specific adsorption of the PWM secondary lymphocytes to the target cells. What adhesion did take place in the presence of cytochalasin B was found to be nonspecific. Ultrastructurally, the contact between lymphocyte and target cells was altered by the drug, when pseudopods were not observed. Possible effects of cytochalasin B on lymphocyte mediated cytolysis, mainly by its effect on microfilament function, are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 709-717 |
| Number of pages | 9 |
| Journal | Immunological Communications |
| Volume | 29 |
| Issue number | 4 |
| State | Published - 1975 |