The effect of cyclophosphamide pulse therapy given in relatively small doses (10 mg/kg per pulse in 17 females with lupus nephritis has been studied. Four females developed menopause; in one transient amenorrhea occurred. No changes in menstrual cycle were noted in the other 11 females, four of whom subsequently delivered five normal babies. These data suggest the relative safety of small doses of cyclophosphamide pulse therapy on gonadal function in females under age 40 years.
|Number of pages||2|
|Journal||American Journal of Reproductive Immunology|
|State||Published - 1992|
- Lupus nephritis