Abstract
Objective: We describe calcium homeostasis during pregestation and gestation in a woman with iatrogenic hypoparathyroidism, treated with continuous subcutaneous recombinant parathyroid hormone (PTH) (1-34) infusion. Results: The requirement for PTH did not fluctuate much during pregnancy and was essential for maintaining normal calcium and phosphorus serum levels. Conclusions: This study documents the insufficiency of PTH-related protein (PTHrP) or other gestation-related hormones to compensate for PTH deficiency in hypoparathyroid women, and the successful utilization of continuous subcutaneous recombinant PTH (1-34) infusion to achieve normal calcium homeostasis during gestation. Clinical trials with PTH replacement in such circumstances are warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 807-810 |
| Number of pages | 4 |
| Journal | Gynecological Endocrinology |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2013 |
| Externally published | Yes |
Keywords
- Calcium
- PTH
- Pregnancy