The effect of compressive deformations on the rate of build-up of oxygen in isolated skeletal muscle cells

Efrat Leopold, Ran Sopher, Amit Gefen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In this study we integrated between confocal-based cell-specific finite element (FE) modeling and Virtual Cell (VC) transport simulations in order to determine trends of relationship between externally applied compressive deformations and build-up rates of oxygen in myoblast cells, and to further test how mild culture temperature drops (~3. °C) might affect such trends. Geometries of two different cells were used, and each FE cell model was computationally subjected to large compressive deformations. Build-up of oxygen concentrations within the deformed cell shapes over time were calculated using the VC software. We found that the build-up of oxygen in the cells was slightly but consistently hindered when compressive cell deformations were applied. Temperature drops characteristic to ischemic conditions further hinder the oxygen built-up in cells. In a real-world condition, a combination of the deformation and temperature factors should be anticipated, and their combined effect might substantially impair cell respiration functions.

Original languageEnglish
Pages (from-to)1072-1078
Number of pages7
JournalMedical Engineering and Physics
Volume33
Issue number9
DOIs
StatePublished - Nov 2011

Funding

FundersFunder number
Ministry of Research, Taiwan
Ministry of Science and Technology, Israel

    Keywords

    • Cell model
    • Deep tissue injury
    • Deformation
    • Diffusion
    • Pressure ulcer

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