TY - JOUR
T1 - The Effect of Clomiphene Citrate and Tamoxifen on the Cervical Mucus
AU - Tepper, Ron
AU - Lunenfeld, Bruno
AU - Shalev, Joseph
AU - Ovadia, Jardena
AU - Blankstein, Josef
PY - 1988/1
Y1 - 1988/1
N2 - The anti‐estrogenic effect of clomiphene citrate (CC) and tamoxifen (TMX) on cervical mucus was evaluated in a prospective crossover study. Ten women underwent randomized alternate cyclical treatment with either 100 mg CC, 40 mg TMX daily, or with placebo. The effect of CC, TMX and placebo on serum estradiol (E2), cervical mucus secretion and on the development of ovarian follicles was evaluated. Compared with placebo, treatment with CC and TMX significantly increased the number of mature ovarian follicles on the day of assumed ovulation (p <0.05), elevated E, secretion (p <0.05) and decreased cervical score (p <0.05). It can be concluded that anti‐estrogenic agents reduced the secretion of cervical mucus. However, in most cases, the excessive E, production due to multiple follicular growth overcomes the anti‐estrogenic effect. 1988 Acta Obstet Gynecol Scand
AB - The anti‐estrogenic effect of clomiphene citrate (CC) and tamoxifen (TMX) on cervical mucus was evaluated in a prospective crossover study. Ten women underwent randomized alternate cyclical treatment with either 100 mg CC, 40 mg TMX daily, or with placebo. The effect of CC, TMX and placebo on serum estradiol (E2), cervical mucus secretion and on the development of ovarian follicles was evaluated. Compared with placebo, treatment with CC and TMX significantly increased the number of mature ovarian follicles on the day of assumed ovulation (p <0.05), elevated E, secretion (p <0.05) and decreased cervical score (p <0.05). It can be concluded that anti‐estrogenic agents reduced the secretion of cervical mucus. However, in most cases, the excessive E, production due to multiple follicular growth overcomes the anti‐estrogenic effect. 1988 Acta Obstet Gynecol Scand
KW - Cervix mucus
KW - anti‐estrogens
KW - estradiol
UR - http://www.scopus.com/inward/record.url?scp=0023682035&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0412.1988.tb07805.x
DO - 10.1111/j.1600-0412.1988.tb07805.x
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C2 - 3051880
AN - SCOPUS:0023682035
SN - 0001-6349
VL - 67
SP - 311
EP - 314
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
IS - 4
ER -