TY - JOUR
T1 - The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD
AU - Simchon, Y.
AU - Weizman, A.
AU - Rehavi, M.
N1 - Funding Information:
The study was supported by a grant from the Dr. Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Tel-Aviv University, Israel .
PY - 2010/10
Y1 - 2010/10
N2 - Dysregulations in monoaminergic systems have been implicated in attention deficit/hyperactivity disorder. The spontaneous hypertensive rats (SHR) are used as an animal model for ADHD. Juvenile SHR rats exhibited low dopamine transporter (DAT) density, low vesicular monoamine transporter 2 (VMAT2) density and lower unstimulated dopamine (DA) release in comparison to their corresponding WKY controls. Chronic methylphenidate treatment of the young SHR rats was associated with lower DAT density and lower unstimulated basal dopamine release but with enhanced potassium- and amphetamine-induced dopamine release. These neurochemical alterations might be relevant to the pathophysiology and to the beneficial effect of methylphenidate in ADHD.
AB - Dysregulations in monoaminergic systems have been implicated in attention deficit/hyperactivity disorder. The spontaneous hypertensive rats (SHR) are used as an animal model for ADHD. Juvenile SHR rats exhibited low dopamine transporter (DAT) density, low vesicular monoamine transporter 2 (VMAT2) density and lower unstimulated dopamine (DA) release in comparison to their corresponding WKY controls. Chronic methylphenidate treatment of the young SHR rats was associated with lower DAT density and lower unstimulated basal dopamine release but with enhanced potassium- and amphetamine-induced dopamine release. These neurochemical alterations might be relevant to the pathophysiology and to the beneficial effect of methylphenidate in ADHD.
KW - Attention deficit hyperactivity disorder (ADHD)
KW - Dopamine transporter (DAT)
KW - Methylphenidate (MPH)
KW - Spontaneous hypertensive rats (SHR)
KW - Vesicular monoamine transporter 2 (VMAT2)
KW - Wistar Kyoto rats (WKY)
UR - http://www.scopus.com/inward/record.url?scp=77956169584&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2010.04.007
DO - 10.1016/j.euroneuro.2010.04.007
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AN - SCOPUS:77956169584
SN - 0924-977X
VL - 20
SP - 714
EP - 720
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 10
ER -
