The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD

Y. Simchon, A. Weizman, M. Rehavi

Research output: Contribution to journalArticlepeer-review

Abstract

Dysregulations in monoaminergic systems have been implicated in attention deficit/hyperactivity disorder. The spontaneous hypertensive rats (SHR) are used as an animal model for ADHD. Juvenile SHR rats exhibited low dopamine transporter (DAT) density, low vesicular monoamine transporter 2 (VMAT2) density and lower unstimulated dopamine (DA) release in comparison to their corresponding WKY controls. Chronic methylphenidate treatment of the young SHR rats was associated with lower DAT density and lower unstimulated basal dopamine release but with enhanced potassium- and amphetamine-induced dopamine release. These neurochemical alterations might be relevant to the pathophysiology and to the beneficial effect of methylphenidate in ADHD.

Original languageEnglish
Pages (from-to)714-720
Number of pages7
JournalEuropean Neuropsychopharmacology
Volume20
Issue number10
DOIs
StatePublished - Oct 2010

Keywords

  • Attention deficit hyperactivity disorder (ADHD)
  • Dopamine transporter (DAT)
  • Methylphenidate (MPH)
  • Spontaneous hypertensive rats (SHR)
  • Vesicular monoamine transporter 2 (VMAT2)
  • Wistar Kyoto rats (WKY)

Fingerprint

Dive into the research topics of 'The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD'. Together they form a unique fingerprint.

Cite this