The effect of chronic lithium pretreatment on rat brain muscarinic receptor regulation

Aharon Levy; Joseph Zohar; Robert H. Belmaker

doi:10.1016/0028-3908(82)90180-0

The effect of chronic lithium pretreatment on rat brain muscarinic receptor regulation

Aharon Levy^*, Joseph Zohar, Robert H. Belmaker

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of two weeks of lithium (Li) pretreatment on up and down regulation of muscarinic receptors in rat brain was measured in two groups of rats. After two weeks of feeding 0.2% LiCl in ground pellets, one group of rats was injected with atropine (3 mg/kg daily for 5 days) and another group with diisopropyl fluorophosphate, a cholinesterase inhibitor (1.2 mg/kg). Li pretreatment completely abolishes the significant 23% rise in QNB binding induced by atropine but does not prevent the significant 16% decline in QNB binding induced by DFP. These results suggest that chronic Li pretreatment prevents supersensitivity but does not prevent subsensitivity of rat brain muscarinic receptors.

Original language	English
Pages (from-to)	1199-1201
Number of pages	3
Journal	Neuropharmacology
Volume	21
Issue number	11
DOIs	https://doi.org/10.1016/0028-3908(82)90180-0
State	Published - Nov 1982
Externally published	Yes

Access to Document

10.1016/0028-3908(82)90180-0

Cite this

@article{3a92f839926d45d7a584e60118a32bd8,

title = "The effect of chronic lithium pretreatment on rat brain muscarinic receptor regulation",

abstract = "The effect of two weeks of lithium (Li) pretreatment on up and down regulation of muscarinic receptors in rat brain was measured in two groups of rats. After two weeks of feeding 0.2% LiCl in ground pellets, one group of rats was injected with atropine (3 mg/kg daily for 5 days) and another group with diisopropyl fluorophosphate, a cholinesterase inhibitor (1.2 mg/kg). Li pretreatment completely abolishes the significant 23% rise in QNB binding induced by atropine but does not prevent the significant 16% decline in QNB binding induced by DFP. These results suggest that chronic Li pretreatment prevents supersensitivity but does not prevent subsensitivity of rat brain muscarinic receptors.",

author = "Aharon Levy and Joseph Zohar and Belmaker, {Robert H.}",

year = "1982",

month = nov,

doi = "10.1016/0028-3908(82)90180-0",

language = "אנגלית",

volume = "21",

pages = "1199--1201",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Ltd.",

number = "11",

}

TY - JOUR

T1 - The effect of chronic lithium pretreatment on rat brain muscarinic receptor regulation

AU - Levy, Aharon

AU - Zohar, Joseph

AU - Belmaker, Robert H.

PY - 1982/11

Y1 - 1982/11

N2 - The effect of two weeks of lithium (Li) pretreatment on up and down regulation of muscarinic receptors in rat brain was measured in two groups of rats. After two weeks of feeding 0.2% LiCl in ground pellets, one group of rats was injected with atropine (3 mg/kg daily for 5 days) and another group with diisopropyl fluorophosphate, a cholinesterase inhibitor (1.2 mg/kg). Li pretreatment completely abolishes the significant 23% rise in QNB binding induced by atropine but does not prevent the significant 16% decline in QNB binding induced by DFP. These results suggest that chronic Li pretreatment prevents supersensitivity but does not prevent subsensitivity of rat brain muscarinic receptors.

AB - The effect of two weeks of lithium (Li) pretreatment on up and down regulation of muscarinic receptors in rat brain was measured in two groups of rats. After two weeks of feeding 0.2% LiCl in ground pellets, one group of rats was injected with atropine (3 mg/kg daily for 5 days) and another group with diisopropyl fluorophosphate, a cholinesterase inhibitor (1.2 mg/kg). Li pretreatment completely abolishes the significant 23% rise in QNB binding induced by atropine but does not prevent the significant 16% decline in QNB binding induced by DFP. These results suggest that chronic Li pretreatment prevents supersensitivity but does not prevent subsensitivity of rat brain muscarinic receptors.

UR - http://www.scopus.com/inward/record.url?scp=0020425130&partnerID=8YFLogxK

U2 - 10.1016/0028-3908(82)90180-0

DO - 10.1016/0028-3908(82)90180-0

M3 - מאמר

AN - SCOPUS:0020425130

VL - 21

SP - 1199

EP - 1201

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 11

ER -

The effect of chronic lithium pretreatment on rat brain muscarinic receptor regulation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this