The effect of cholinesterase inhibition on the ontogenesis of central muscarinic receptors

Aharon Levy

doi:10.1016/0024-3205(81)90468-9

The effect of cholinesterase inhibition on the ontogenesis of central muscarinic receptors

Research output: Contribution to journal › Article › peer-review

Abstract

The density of specific ³H-quinuclidinyl benzilate binding-sites in mouse brain was found to increase during ontogenic development from 0.51±0.08 pmoles/mg protein at day 8 postpartum to 1.54± 0.04 pmoles/mg protein at day 20. Repeated injections of the cholinesterase inhibitor diisopropyl flourophophase (1 mg/kg) at days 8, 10, 12 and 14 resulted in gradual decrease in the number of binding-sites, while apparent K_D values remained unchanged (0.24±0.03 nM). Following termination of this treatment, the density of binding-sites approached the control levels within a few days.

Original language	English
Pages (from-to)	1065-1070
Number of pages	6
Journal	Life Sciences
Volume	29
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(81)90468-9
State	Published - 7 Sep 1981
Externally published	Yes

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10.1016/0024-3205(81)90468-9

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title = "The effect of cholinesterase inhibition on the ontogenesis of central muscarinic receptors",

abstract = "The density of specific 3H-quinuclidinyl benzilate binding-sites in mouse brain was found to increase during ontogenic development from 0.51±0.08 pmoles/mg protein at day 8 postpartum to 1.54± 0.04 pmoles/mg protein at day 20. Repeated injections of the cholinesterase inhibitor diisopropyl flourophophase (1 mg/kg) at days 8, 10, 12 and 14 resulted in gradual decrease in the number of binding-sites, while apparent KD values remained unchanged (0.24±0.03 nM). Following termination of this treatment, the density of binding-sites approached the control levels within a few days.",

author = "Aharon Levy",

year = "1981",

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doi = "10.1016/0024-3205(81)90468-9",

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AB - The density of specific 3H-quinuclidinyl benzilate binding-sites in mouse brain was found to increase during ontogenic development from 0.51±0.08 pmoles/mg protein at day 8 postpartum to 1.54± 0.04 pmoles/mg protein at day 20. Repeated injections of the cholinesterase inhibitor diisopropyl flourophophase (1 mg/kg) at days 8, 10, 12 and 14 resulted in gradual decrease in the number of binding-sites, while apparent KD values remained unchanged (0.24±0.03 nM). Following termination of this treatment, the density of binding-sites approached the control levels within a few days.

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The effect of cholinesterase inhibition on the ontogenesis of central muscarinic receptors

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