The effect of cholinesterase inhibition on the ontogenesis of central muscarinic receptors

Research output: Contribution to journalArticlepeer-review

Abstract

The density of specific 3H-quinuclidinyl benzilate binding-sites in mouse brain was found to increase during ontogenic development from 0.51±0.08 pmoles/mg protein at day 8 postpartum to 1.54± 0.04 pmoles/mg protein at day 20. Repeated injections of the cholinesterase inhibitor diisopropyl flourophophase (1 mg/kg) at days 8, 10, 12 and 14 resulted in gradual decrease in the number of binding-sites, while apparent KD values remained unchanged (0.24±0.03 nM). Following termination of this treatment, the density of binding-sites approached the control levels within a few days.

Original languageEnglish
Pages (from-to)1065-1070
Number of pages6
JournalLife Sciences
Volume29
Issue number10
DOIs
StatePublished - 7 Sep 1981
Externally publishedYes

Fingerprint

Dive into the research topics of 'The effect of cholinesterase inhibition on the ontogenesis of central muscarinic receptors'. Together they form a unique fingerprint.

Cite this