The effect of chlorthalidone on serum lipids and lipoproteins

Talma Rosenthal*, Eliezer Holtzman, Pesach Segal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased. Our findings suggest that chlorthalidone increases serum concentrations of "atherogenic" lipoproteins (LDL and VLDL), and possibly decreases the levels of a "beneficial" lipoprotein, namely HDL. Thus, the use of this medication may increase a major atherosclerosis risk factor.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
Issue number1
StatePublished - May 1980


  • Atherogenic risk factors
  • Chlorthalidone
  • Lipoproteins


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