The effect of chlorthalidone on serum lipids and lipoproteins

Talma Rosenthal, Eliezer Holtzman, Pesach Segal

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased. Our findings suggest that chlorthalidone increases serum concentrations of "atherogenic" lipoproteins (LDL and VLDL), and possibly decreases the levels of a "beneficial" lipoprotein, namely HDL. Thus, the use of this medication may increase a major atherosclerosis risk factor.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalAtherosclerosis
Volume36
Issue number1
DOIs
StatePublished - May 1980

Keywords

  • Atherogenic risk factors
  • Chlorthalidone
  • Lipoproteins

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