TY - JOUR
T1 - The effect of antimicrobial resistance on patient outcomes
T2 - importance of proper evaluation of appropriate therapy.
AU - Schwaber, Mitchell J.
AU - Carmeli, Yehuda
PY - 2009
Y1 - 2009
N2 - The impact of antimicrobial resistance on patient outcomes can be effectively measured only if the appropriateness of the antimicrobial therapy received is properly measured. Definition of appropriate therapy should include not only in vitro susceptibility but also the clinical adequacy of the antibiotic used, taking into account the pathogen isolated, the site of infection, known pharmacokinetic and pharmacodynamic properties of the drug, and dosing. In the absence of these data, the effect of delay or absence of appropriate therapy in patients infected with resistant bacterial pathogens is subject to confounding, and the true effect of resistance on outcomes may be obscured.
AB - The impact of antimicrobial resistance on patient outcomes can be effectively measured only if the appropriateness of the antimicrobial therapy received is properly measured. Definition of appropriate therapy should include not only in vitro susceptibility but also the clinical adequacy of the antibiotic used, taking into account the pathogen isolated, the site of infection, known pharmacokinetic and pharmacodynamic properties of the drug, and dosing. In the absence of these data, the effect of delay or absence of appropriate therapy in patients infected with resistant bacterial pathogens is subject to confounding, and the true effect of resistance on outcomes may be obscured.
UR - http://www.scopus.com/inward/record.url?scp=77449104841&partnerID=8YFLogxK
U2 - 10.1186/cc7136
DO - 10.1186/cc7136
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.comment???
C2 - 19216721
AN - SCOPUS:77449104841
SN - 1364-8535
VL - 13
SP - 106
JO - Critical Care
JF - Critical Care
IS - 1
ER -