The effect of active immunization on varicella-related hospitalizations in Israel

Liat Lerner-Geva; Galit Hirsh-Yechezkel; Ilia Novikov; Hagit Farkash; Valentina Boyko; Zvi Spirer; Justen H. Passwell

doi:10.4161/hv.5.3.6811

The effect of active immunization on varicella-related hospitalizations in Israel

Liat Lerner-Geva^*, Galit Hirsh-Yechezkel, Ilia Novikov, Hagit Farkash, Valentina Boyko, Zvi Spirer, Justen H. Passwell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study is to report on the impact of introduction of the varicella vaccine "Varilix" on hospitalizations due to varicella, following licensure in Israel in June, 2000. Data on children hospitalized throughout Israel with the diagnosis of varicella were collected from 1998 until 2003. The national rate of varicella-related hospitalizations decreased during the period 2001-2002. However in 2003 an increase in hospitalization occurred. Based on an assumption that at least 22,000 vaccinations per year were administered, we estimate that there is a greater than 60% reduction in the risk for hospitalization in the immunized population (RR = 0.32; 0.10-1.00). In summary, no national trend in reduction of hospitalization has yet been observed, but a significant reduction in hospitalization is apparent for vaccinated children.

Original language	English
Pages (from-to)	136-140
Number of pages	5
Journal	Human Vaccines
Volume	5
Issue number	3
DOIs	https://doi.org/10.4161/hv.5.3.6811
State	Published - 2009

Keywords

Children
Hospitalization
Immunization
Vaccine
Varicella

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/hv.5.3.6811

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title = "The effect of active immunization on varicella-related hospitalizations in Israel",

abstract = "The purpose of this study is to report on the impact of introduction of the varicella vaccine {"}Varilix{"} on hospitalizations due to varicella, following licensure in Israel in June, 2000. Data on children hospitalized throughout Israel with the diagnosis of varicella were collected from 1998 until 2003. The national rate of varicella-related hospitalizations decreased during the period 2001-2002. However in 2003 an increase in hospitalization occurred. Based on an assumption that at least 22,000 vaccinations per year were administered, we estimate that there is a greater than 60% reduction in the risk for hospitalization in the immunized population (RR = 0.32; 0.10-1.00). In summary, no national trend in reduction of hospitalization has yet been observed, but a significant reduction in hospitalization is apparent for vaccinated children.",

keywords = "Children, Hospitalization, Immunization, Vaccine, Varicella",

author = "Liat Lerner-Geva and Galit Hirsh-Yechezkel and Ilia Novikov and Hagit Farkash and Valentina Boyko and Zvi Spirer and Passwell, {Justen H.}",

note = "Funding Information: This work was supported in part by a grant from GSK, Biologicals.",

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doi = "10.4161/hv.5.3.6811",

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AU - Lerner-Geva, Liat

AU - Hirsh-Yechezkel, Galit

AU - Novikov, Ilia

AU - Farkash, Hagit

AU - Boyko, Valentina

AU - Spirer, Zvi

AU - Passwell, Justen H.

N1 - Funding Information: This work was supported in part by a grant from GSK, Biologicals.

PY - 2009

Y1 - 2009

N2 - The purpose of this study is to report on the impact of introduction of the varicella vaccine "Varilix" on hospitalizations due to varicella, following licensure in Israel in June, 2000. Data on children hospitalized throughout Israel with the diagnosis of varicella were collected from 1998 until 2003. The national rate of varicella-related hospitalizations decreased during the period 2001-2002. However in 2003 an increase in hospitalization occurred. Based on an assumption that at least 22,000 vaccinations per year were administered, we estimate that there is a greater than 60% reduction in the risk for hospitalization in the immunized population (RR = 0.32; 0.10-1.00). In summary, no national trend in reduction of hospitalization has yet been observed, but a significant reduction in hospitalization is apparent for vaccinated children.

AB - The purpose of this study is to report on the impact of introduction of the varicella vaccine "Varilix" on hospitalizations due to varicella, following licensure in Israel in June, 2000. Data on children hospitalized throughout Israel with the diagnosis of varicella were collected from 1998 until 2003. The national rate of varicella-related hospitalizations decreased during the period 2001-2002. However in 2003 an increase in hospitalization occurred. Based on an assumption that at least 22,000 vaccinations per year were administered, we estimate that there is a greater than 60% reduction in the risk for hospitalization in the immunized population (RR = 0.32; 0.10-1.00). In summary, no national trend in reduction of hospitalization has yet been observed, but a significant reduction in hospitalization is apparent for vaccinated children.

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KW - Hospitalization

KW - Immunization

KW - Vaccine

KW - Varicella

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The effect of active immunization on varicella-related hospitalizations in Israel

Abstract

Keywords

UN SDGs

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