The Domino Effect in EGFR-ERK Signaling

Udi Binshtok; David Sprinzak

doi:10.1016/j.devcel.2018.06.021

The Domino Effect in EGFR-ERK Signaling

Udi Binshtok
, David Sprinzak^*

^*Corresponding author for this work

Biochemistry Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

A gradient of EGFR-ERK signaling has been classically implicated in various developmental processes. In this issue of Developmental Cell, Ogura et al. (2018) show that in the Drosophila tracheal placode, EGFR-ERK signaling propagates via a cell-by-cell relay mechanism rather than a gradient, and this sequential ERK activation controls proper placode invagination.

Original language	English
Pages (from-to)	128-130
Number of pages	3
Journal	Developmental Cell
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2018.06.021
State	Published - 16 Jul 2018

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10.1016/j.devcel.2018.06.021

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title = "The Domino Effect in EGFR-ERK Signaling",

abstract = "A gradient of EGFR-ERK signaling has been classically implicated in various developmental processes. In this issue of Developmental Cell, Ogura et al. (2018) show that in the Drosophila tracheal placode, EGFR-ERK signaling propagates via a cell-by-cell relay mechanism rather than a gradient, and this sequential ERK activation controls proper placode invagination.",

author = "Udi Binshtok and David Sprinzak",

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AB - A gradient of EGFR-ERK signaling has been classically implicated in various developmental processes. In this issue of Developmental Cell, Ogura et al. (2018) show that in the Drosophila tracheal placode, EGFR-ERK signaling propagates via a cell-by-cell relay mechanism rather than a gradient, and this sequential ERK activation controls proper placode invagination.

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JO - Developmental Cell

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The Domino Effect in EGFR-ERK Signaling

Abstract

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