TY - JOUR
T1 - The distribution of relaxin receptors in the anterior segment of primary open-angle glaucoma patients
AU - Zloto, Ofira
AU - Skaat, Alon
AU - Fabian, Ido Didi
AU - Rosner, Mordechai
AU - Ziv, Hana
AU - Leshno, Ari
AU - Melamed, Shlomo
N1 - Publisher Copyright:
© 2020 Indian Journal of Ophthalmology | Published by Wolters Kluwer - Medknow
PY - 2020/10
Y1 - 2020/10
N2 - Purpose: Relaxin is a polypeptide hormone produced by the corpus luteum and the decidua in females and by the prostate in males. It has vasodilatory and antifibrotic effects. In the past, it has been reported that injection of relaxin hormone has caused a reduction in the intraocular pressure although its mechanism has not yet been fully understood and the expression of relaxin receptors has not yet been evident in the human eye. Therefore, the purpose of this current study was to examine the presence of relaxin receptors in the human eye anterior segment. Methods: This is an interventional non-randomized study. Patients with primary open-angle glaucoma who underwent trabeculectomy were recruited. During the surgery, a punch biopsy (including the cornea, sclera, trabecular meshwork, and Schlemm's canal) was taken and stained with hematoxylin-eosin, and immunohistochemistry staining for relaxin/insulin-like family peptide receptor 1 (RXFP1). Results: A positive staining was noted for RXFP1 in the inner uveal, corneoscleral, and cribriform meshwork and Schlemm's canal's endothelium. Negative staining for RXFP1 was noted in the cornea and sclera. Conclusion: RXFP1 is present in the anterior segment drainage system of the human eye. Therefore, this receptor may have an active role in regulating the outflow facility and in the reduction of intraocular pressure.
AB - Purpose: Relaxin is a polypeptide hormone produced by the corpus luteum and the decidua in females and by the prostate in males. It has vasodilatory and antifibrotic effects. In the past, it has been reported that injection of relaxin hormone has caused a reduction in the intraocular pressure although its mechanism has not yet been fully understood and the expression of relaxin receptors has not yet been evident in the human eye. Therefore, the purpose of this current study was to examine the presence of relaxin receptors in the human eye anterior segment. Methods: This is an interventional non-randomized study. Patients with primary open-angle glaucoma who underwent trabeculectomy were recruited. During the surgery, a punch biopsy (including the cornea, sclera, trabecular meshwork, and Schlemm's canal) was taken and stained with hematoxylin-eosin, and immunohistochemistry staining for relaxin/insulin-like family peptide receptor 1 (RXFP1). Results: A positive staining was noted for RXFP1 in the inner uveal, corneoscleral, and cribriform meshwork and Schlemm's canal's endothelium. Negative staining for RXFP1 was noted in the cornea and sclera. Conclusion: RXFP1 is present in the anterior segment drainage system of the human eye. Therefore, this receptor may have an active role in regulating the outflow facility and in the reduction of intraocular pressure.
KW - Drainage system
KW - Glaucoma
KW - Relaxin
KW - Schlemm's canal
UR - http://www.scopus.com/inward/record.url?scp=85091616542&partnerID=8YFLogxK
U2 - 10.4103/ijo.IJO_2008_19
DO - 10.4103/ijo.IJO_2008_19
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C2 - 32971620
AN - SCOPUS:85091616542
SN - 0301-4738
VL - 68
SP - 2117
EP - 2120
JO - Indian Journal of Ophthalmology
JF - Indian Journal of Ophthalmology
IS - 10
ER -