The distinct structural preferences of tau protein repeat domains

Xuhua Li, Xuewei Dong, Guanghong Wei*, Martin Margittai, Ruth Nussinov, Buyong Ma

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.

Original languageEnglish
Pages (from-to)5700-5703
Number of pages4
JournalChemical Communications
Volume54
Issue number45
DOIs
StatePublished - 2018

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