@article{f2301ecc83a94899ba0b7e300ed94c53,
title = "The distinct structural preferences of tau protein repeat domains",
abstract = "The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.",
author = "Xuhua Li and Xuewei Dong and Guanghong Wei and Martin Margittai and Ruth Nussinov and Buyong Ma",
note = "Publisher Copyright: {\textcopyright}2018 The Royal Society of Chemistry.",
year = "2018",
doi = "10.1039/c8cc01263f",
language = "אנגלית",
volume = "54",
pages = "5700--5703",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "45",
}