The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts

Sarah P. Georgiadou, Nikolaos V. Sipsas, Edith M. Marom, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticlepeer-review

Abstract

The halo sign is a CT finding of ground-glass opacity surrounding a pulmonary nodule or mass. The reversed halo sign is a focal rounded area of ground-glass opacity surrounded by a crescent or complete ring of consolidation. In severely immunocompromised patients, these signs are highly suggestive of early infection by an angioinvasive fungus. The halo sign and reversed halo sign are most commonly associated with invasive pulmonary aspergillosis and pulmonary mucormycosis, respectively. Many other infections and noninfectious conditions, such as neoplastic and inflammatory processes, may also manifest with pulmonary nodules associated with either sign. Although nonspecific, both signs can be useful for preemptive initiation of antifungal therapy in the appropriate clinical setting. This review aims to evaluate the diagnostic value of the halo sign and reversed halo sign in immunocompromised hosts and describes the wide spectrum of diseases associated with them.

Original languageEnglish
Pages (from-to)1144-1155
Number of pages12
JournalClinical Infectious Diseases
Volume52
Issue number9
DOIs
StatePublished - 1 May 2011
Externally publishedYes

Fingerprint

Dive into the research topics of 'The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts'. Together they form a unique fingerprint.

Cite this