TY - JOUR
T1 - The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts
AU - Georgiadou, Sarah P.
AU - Sipsas, Nikolaos V.
AU - Marom, Edith M.
AU - Kontoyiannis, Dimitrios P.
N1 - Funding Information:
Financial Support. This work was supported by the Amphiarion Foundation of Chemotherapeutic Studies (to S.P.G.), the Special Account for Research Funds (E.L.K.E.) of the National and Kapodistrian University of Athens (to N.V.S. and S.P.G.), and the National Institutes of Health through an MD Anderson Cancer Center Support Grant (CA016672).
Funding Information:
Potential conflicts of interest. D.P.K. is a consultant and board member and received payment for lectures from Schering-Plough, Pfizer, and Astellas Pharma US; and has received grant support from Astellas Pharma US and Merck; and has received honorarium from Enzon Pharmaceuticals. All other authors: no conflicts.
PY - 2011/5/1
Y1 - 2011/5/1
N2 - The halo sign is a CT finding of ground-glass opacity surrounding a pulmonary nodule or mass. The reversed halo sign is a focal rounded area of ground-glass opacity surrounded by a crescent or complete ring of consolidation. In severely immunocompromised patients, these signs are highly suggestive of early infection by an angioinvasive fungus. The halo sign and reversed halo sign are most commonly associated with invasive pulmonary aspergillosis and pulmonary mucormycosis, respectively. Many other infections and noninfectious conditions, such as neoplastic and inflammatory processes, may also manifest with pulmonary nodules associated with either sign. Although nonspecific, both signs can be useful for preemptive initiation of antifungal therapy in the appropriate clinical setting. This review aims to evaluate the diagnostic value of the halo sign and reversed halo sign in immunocompromised hosts and describes the wide spectrum of diseases associated with them.
AB - The halo sign is a CT finding of ground-glass opacity surrounding a pulmonary nodule or mass. The reversed halo sign is a focal rounded area of ground-glass opacity surrounded by a crescent or complete ring of consolidation. In severely immunocompromised patients, these signs are highly suggestive of early infection by an angioinvasive fungus. The halo sign and reversed halo sign are most commonly associated with invasive pulmonary aspergillosis and pulmonary mucormycosis, respectively. Many other infections and noninfectious conditions, such as neoplastic and inflammatory processes, may also manifest with pulmonary nodules associated with either sign. Although nonspecific, both signs can be useful for preemptive initiation of antifungal therapy in the appropriate clinical setting. This review aims to evaluate the diagnostic value of the halo sign and reversed halo sign in immunocompromised hosts and describes the wide spectrum of diseases associated with them.
UR - http://www.scopus.com/inward/record.url?scp=79953842942&partnerID=8YFLogxK
U2 - 10.1093/cid/cir122
DO - 10.1093/cid/cir122
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 21467021
AN - SCOPUS:79953842942
VL - 52
SP - 1144
EP - 1155
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 9
ER -
