TY - JOUR
T1 - The diagnostic performance of ultrafast MRI to differentiate benign from malignant breast lesions
T2 - a systematic review and meta-analysis
AU - Amitai, Yoav
AU - Freitas, Vivianne A.R.
AU - Golan, Orit
AU - Kessner, Rivka
AU - Shalmon, Tamar
AU - Neeman, Rina
AU - Mauda-Havakuk, Michal
AU - Mercer, Diego
AU - Sklair-Levy, Miri
AU - Menes, Tehillah S.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/10
Y1 - 2024/10
N2 - Objectives: To assess the diagnostic performance of ultrafast magnetic resonance imaging (UF-DCE MRI) in differentiating benign from malignant breast lesions. Materials and methods: A comprehensive search was conducted until September 1, 2023, in Medline, Embase, and Cochrane databases. Clinical studies evaluating the diagnostic performance of UF-DCE MRI in breast lesion stratification were screened and included in the meta-analysis. Pooled summary estimates for sensitivity, specificity, diagnostic odds ratio (DOR), and hierarchic summary operating characteristics (SROC) curves were pooled under the random-effects model. Publication bias and heterogeneity between studies were calculated. Results: A final set of 16 studies analyzing 2090 lesions met the inclusion criteria and were incorporated into the meta-analysis. Using UF-DCE MRI kinetic parameters, the pooled sensitivity, specificity, DOR, and area under the curve (AUC) for differentiating benign from malignant breast lesions were 83% (95% CI 79–88%), 77% (95% CI 72–83%), 18.9 (95% CI 13.7–26.2), and 0.876 (95% CI 0.83–0.887), respectively. We found no significant difference in diagnostic accuracy between the two main UF-DCE MRI kinetic parameters, maximum slope (MS) and time to enhancement (TTE). DOR and SROC exhibited low heterogeneity across the included studies. No evidence of publication bias was identified (p = 0.585). Conclusions: UF-DCE MRI as a stand-alone technique has high accuracy in discriminating benign from malignant breast lesions. Clinical relevance statement: UF-DCE MRI has the potential to obtain kinetic information and stratify breast lesions accurately while decreasing scan times, which may offer significant benefit to patients. Key Points: • Ultrafast breast MRI is a novel technique which captures kinetic information with very high temporal resolution. • The kinetic parameters of ultrafast breast MRI demonstrate a high level of accuracy in distinguishing between benign and malignant breast lesions. • There is no significant difference in accuracy between maximum slope and time to enhancement kinetic parameters.
AB - Objectives: To assess the diagnostic performance of ultrafast magnetic resonance imaging (UF-DCE MRI) in differentiating benign from malignant breast lesions. Materials and methods: A comprehensive search was conducted until September 1, 2023, in Medline, Embase, and Cochrane databases. Clinical studies evaluating the diagnostic performance of UF-DCE MRI in breast lesion stratification were screened and included in the meta-analysis. Pooled summary estimates for sensitivity, specificity, diagnostic odds ratio (DOR), and hierarchic summary operating characteristics (SROC) curves were pooled under the random-effects model. Publication bias and heterogeneity between studies were calculated. Results: A final set of 16 studies analyzing 2090 lesions met the inclusion criteria and were incorporated into the meta-analysis. Using UF-DCE MRI kinetic parameters, the pooled sensitivity, specificity, DOR, and area under the curve (AUC) for differentiating benign from malignant breast lesions were 83% (95% CI 79–88%), 77% (95% CI 72–83%), 18.9 (95% CI 13.7–26.2), and 0.876 (95% CI 0.83–0.887), respectively. We found no significant difference in diagnostic accuracy between the two main UF-DCE MRI kinetic parameters, maximum slope (MS) and time to enhancement (TTE). DOR and SROC exhibited low heterogeneity across the included studies. No evidence of publication bias was identified (p = 0.585). Conclusions: UF-DCE MRI as a stand-alone technique has high accuracy in discriminating benign from malignant breast lesions. Clinical relevance statement: UF-DCE MRI has the potential to obtain kinetic information and stratify breast lesions accurately while decreasing scan times, which may offer significant benefit to patients. Key Points: • Ultrafast breast MRI is a novel technique which captures kinetic information with very high temporal resolution. • The kinetic parameters of ultrafast breast MRI demonstrate a high level of accuracy in distinguishing between benign and malignant breast lesions. • There is no significant difference in accuracy between maximum slope and time to enhancement kinetic parameters.
KW - Artificial intelligence
KW - Breast cancer
KW - Kinetics
KW - Magnetic resonance imaging
KW - Ultrafast
UR - http://www.scopus.com/inward/record.url?scp=85188247625&partnerID=8YFLogxK
U2 - 10.1007/s00330-024-10690-y
DO - 10.1007/s00330-024-10690-y
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C2 - 38512492
AN - SCOPUS:85188247625
SN - 0938-7994
VL - 34
SP - 6285
EP - 6295
JO - European Radiology
JF - European Radiology
IS - 10
ER -
