TY - JOUR
T1 - The development of the fetal eye
T2 - In utero ultrasonographic measurements of the vitreous and lens
AU - Achiron, R.
AU - Gottlieb, Z.
AU - Yaron, Y.
AU - Gabbay, M.
AU - Gabbay, U.
AU - Lipitz, S.
AU - Mashiach, S.
PY - 1995/2
Y1 - 1995/2
N2 - Our objective was to establish nomograms for fetal eye measurements from 12 weeks' gestation by using transvaginal and transabdominal high‐resolution ultrasound techniques. A prospective cross‐sectional study was performed on 450 normal singleton pregnancies between 12 and 37 weeks' gestation. Vitreous and lens circumferences were measured by transvaginal ultrasonography until 17 weeks, and by abdominal ultrasound between 18 and 37 weeks' gestation. Regression analyses were used to create nomograms, and several transformations were done to obtain linearity. Eye measurements of 12 fetuses at risk for ocular disturbances were plotted on the constructed nomograms. Linear relationships were fitted between vitreous (r2=0.79) and lens (r2=0.88) circumferences and gestational age. In addition, there was a significant correlation between these measurements and the biparietal diameter. Data of the fetuses at risk showed that disturbances in ocular growth were associated mainly with abnormal cerebral development. These normative data may be helpful in the prenatal diagnosis of suspected congenital syndromes that include, among their manifestations, ocular growth disturbances such as microphthalmos and anophthalmos.
AB - Our objective was to establish nomograms for fetal eye measurements from 12 weeks' gestation by using transvaginal and transabdominal high‐resolution ultrasound techniques. A prospective cross‐sectional study was performed on 450 normal singleton pregnancies between 12 and 37 weeks' gestation. Vitreous and lens circumferences were measured by transvaginal ultrasonography until 17 weeks, and by abdominal ultrasound between 18 and 37 weeks' gestation. Regression analyses were used to create nomograms, and several transformations were done to obtain linearity. Eye measurements of 12 fetuses at risk for ocular disturbances were plotted on the constructed nomograms. Linear relationships were fitted between vitreous (r2=0.79) and lens (r2=0.88) circumferences and gestational age. In addition, there was a significant correlation between these measurements and the biparietal diameter. Data of the fetuses at risk showed that disturbances in ocular growth were associated mainly with abnormal cerebral development. These normative data may be helpful in the prenatal diagnosis of suspected congenital syndromes that include, among their manifestations, ocular growth disturbances such as microphthalmos and anophthalmos.
KW - Fetal eye measurements
KW - ultrasonographic studies
UR - http://www.scopus.com/inward/record.url?scp=0028950448&partnerID=8YFLogxK
U2 - 10.1002/pd.1970150208
DO - 10.1002/pd.1970150208
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AN - SCOPUS:0028950448
SN - 0197-3851
VL - 15
SP - 155
EP - 160
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
IS - 2
ER -