The cytoskeletal network controls c-Jun translation in a UTR-dependent manner

P. Polak, A. Oren, I. Ben-Dror, D. Steinberg, S. Sapoznik, A. Arditi-Duvdevany, L. Vardimon

Research output: Contribution to journalArticlepeer-review

Abstract

The cytoskeleton is a dynamic network that undergoes restructuring during various cellular events, influencing cell proliferation, differentiation, and apoptosis. Here, we report that accumulation of c-Jun, a member of the AP1 family of transcription factors that play a key role in normal and aberrant cell growth, dramatically increases upon depolymerization of the cytoskeleton, and that, unexpectedly, this increase is controlled translationally. Depolymerization of the actin or microtubule network induces an increase in c-Jun accumulation with no corresponding increase in c-Jun mRNA or in the half-life of the c-Jun protein, but rather in the translatability of its transcript. This increase is mediated by the untranslated regions (UTRs) of c-Jun mRNA, and is not dependent on activated mitogen-activated protein kinase pathways. This novel mechanism of c-Jun regulation might be relevant to physiological conditions in which c-Jun plays a pivotal role.

Original languageEnglish
Pages (from-to)665-676
Number of pages12
JournalOncogene
Volume25
Issue number5
DOIs
StatePublished - 2 Feb 2006

Keywords

  • Cell density
  • Cytoskeletal network
  • Translation control
  • UTRs
  • c-Jun

Fingerprint

Dive into the research topics of 'The cytoskeletal network controls c-Jun translation in a UTR-dependent manner'. Together they form a unique fingerprint.

Cite this