The CUSCORE test and the q-interval in cluster analyses of colon cancer and of lymphoma among asbestos workers

Rina Chen, P. Froom

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Exposure to a carcinogen is likely to be reflected by temporal clustering of cancer cases among the community members. Detection of such clustering is a complicated task in general and more so in a small workplace community with low turnover rate. In this study we applied the CUSCORE test and the q-interval statistic to lymphoma and colon cancer death data among 2200 asbestos workers. The CUSCORE test was applied in order to identify clusters, and the q-interval was used to provide clues related to the cause of the cluster. We also evaluated and tested the data according to the standardized mortality ratio (SMR). Significant increases in both colon cancer and lymphoma among asbestos workers in Israel (1987-1997) were demonstrated by the CUSCORE test but not so by the SMR. The fact that an apparent clustering was observed from the pattern of the q-intervals leads to the conclusion that the detected clusters are real.

Original languageEnglish
Pages (from-to)3101-3109
Number of pages9
JournalStatistics in Medicine
Volume22
Issue number19
DOIs
StatePublished - 15 Oct 2003

Keywords

  • Asbestos
  • CUSCORE test
  • Colon cancer
  • Disease clustering
  • Lymphoma
  • q-interval

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