TY - JOUR
T1 - The crossed nigrostriatal projection decussates in the ventral tegmental decussation
AU - Douglas, Rodney
AU - Kellaway, Lauriston
AU - Mintz, Matti
AU - Wageningen, Gerhard van
PY - 1987/8/18
Y1 - 1987/8/18
N2 - Horseradish peroxidase (HRP) tract-tracing techniques were used in 44 rats in order to establish the site of decussation of the crossed nigrostriatal projection. Somata in both the ipsilateral and the contralateral ventromedial mesencephalon were labelled after injection of HRP into the caudate nucleus. In agreement with previous studies, contralateral labelling constituted about 3% of the ipsilateral labelling. Midsagittal transection of the mesodiencephalic junction did not prevent the contraleral labelling. However, mid-sagittal transection of the ventral mesencephalon, or selective 6-hydroxydopamine (6-OHDA) lesions of the ventral tegmental decussation did prevent the contralateral labelling. Moreover, 6-OHDA lesions of the substantia nigra ipsilateral to the horseradish peroxidase injection also prevented contralateral labelling. We conclude that the crossed nigrastriatal projection decussates in the ventral tegmental decussation, and that this projection is susceptible to damage by standard 6-OHDA lesions located on the opposite side to the origin of the crossed pathway.
AB - Horseradish peroxidase (HRP) tract-tracing techniques were used in 44 rats in order to establish the site of decussation of the crossed nigrostriatal projection. Somata in both the ipsilateral and the contralateral ventromedial mesencephalon were labelled after injection of HRP into the caudate nucleus. In agreement with previous studies, contralateral labelling constituted about 3% of the ipsilateral labelling. Midsagittal transection of the mesodiencephalic junction did not prevent the contraleral labelling. However, mid-sagittal transection of the ventral mesencephalon, or selective 6-hydroxydopamine (6-OHDA) lesions of the ventral tegmental decussation did prevent the contralateral labelling. Moreover, 6-OHDA lesions of the substantia nigra ipsilateral to the horseradish peroxidase injection also prevented contralateral labelling. We conclude that the crossed nigrastriatal projection decussates in the ventral tegmental decussation, and that this projection is susceptible to damage by standard 6-OHDA lesions located on the opposite side to the origin of the crossed pathway.
KW - 6-Hydroxydopamine
KW - Crossed mesostriatal projection
KW - Crossed nigrostriatal projection
KW - Horseradish peroxidase
KW - Substantia nigra
KW - Ventral tegmental decussation
UR - http://www.scopus.com/inward/record.url?scp=0023635664&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(87)90967-X
DO - 10.1016/0006-8993(87)90967-X
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AN - SCOPUS:0023635664
SN - 0006-8993
VL - 418
SP - 111
EP - 121
JO - Brain Research
JF - Brain Research
IS - 1
ER -