The Creatine Kinase System in Normal and Diseased Myocardium

Alvin M. Kaye, Yosef Weisman, Itzhak Binderman, Dalia Somjen, Arthur J. Siegel, Lawrence M. Silverman, Gary S. Tennyson, Joanne S. Ingwall, Martha F. Kramer, Paul D. Allen

Research output: Contribution to journalLetterpeer-review


To the Editor: Dr. Ingwall and her colleagues,1 in their article in the October 24 issue, raise an important point concerning elevation of creatine kinase MB in the heart, which may be the iceberg-tip of a more general phenomenon - namely, the stimulation of the B isoform of creatine kinase by any agent or situation involving a modulation of energy regeneration. The increase in creatine kinase B, detected in the heart as increased MB isozyme, as part of a compensatory hypertrophy reaction, appears to be basically similar to the increase in creatine kinase BB activity that we have found to.

Original languageEnglish
Pages (from-to)990-991
Number of pages2
JournalNew England Journal of Medicine
Issue number15
StatePublished - 10 Apr 1986
Externally publishedYes


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