@article{6deaa8fe6f7c4a02a2079cf17f08f438,
title = "The Cow{\textquoteright}s Milk-Related Symptom Score (CoMiSS{\texttrademark}): A Useful Awareness Tool",
abstract = "The Cow{\textquoteright}s Milk-related Symptom Score (CoMiSS{\texttrademark}) was developed as a clinical tool aimed at increasing the awareness of health care professionals for the presence and intensity of clinical manifestations possibly related to cow{\textquoteright}s milk (CM) intake. This review summarizes current evidence on CoMiSS. We found twenty-five original studies, one pooled analysis of three studies, and two reviews on CoMiSS. Infants exhibiting symptoms possibly related to CM, present with a higher median CoMiSS (6 to 13; 16 studies) than apparently healthy infants (median from 3 to 4; and mean 3.6–4.7; 5 studies). In children with cow´s milk allergy (CMA), 11 studies found that a CoMiSS of ≥12 predicted a favorable response to a CM-free diet; however, sensitivity (20% to 77%) and specificity (54% to 92%) varied. The decrease of CoMiSS during a CM elimination diet was also predictive of a reaction to an oral food challenge to diagnose CMA. A low CoMiSS (< 6) was predictive for the absence of CMA. It was shown that no special training is required to use the tool in a reliable way. Intra-rater reliability was high with very low variability (intra-class correlation 0.93; 95% confidence interval 0.90–0.96; p < 0.001) in repeated assessments. This review found that CoMiSS cannot be considered as a stand-alone CMA diagnostic tool, but that it is a useful awareness tool for CMA as well as for monitoring symptom improvement.",
keywords = "CoMiSS, cow{\textquoteright}s milk, cow{\textquoteright}s milk allergy, food allergy, infant",
author = "Katerina Bajerova and Silvia Salvatore and Christophe Dupont and Philippe Eigenmann and Mikael Kuitunen and Rosan Meyer and Carmen Ribes-Koninckx and Raanan Shamir and Hania Szajewska and Yvan Vandenplas",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).",
year = "2022",
month = may,
day = "1",
doi = "10.3390/nu14102059",
language = "אנגלית",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",
}