TY - JOUR
T1 - The counseling and management of young healthy BRCA mutation carriers
AU - Eitan, Ram
AU - Michaelson-Cohen, Rachel
AU - Levavi, Hanoch
AU - Beller, Uziel
PY - 2009/10
Y1 - 2009/10
N2 - Although more than 15 years have elapsed since the discovery of the BRCA1 and BRCA2 genes and the associated increased risk of breast and ovarian cancers in mutation carriers, our understanding of the syndrome is still evolving. With the accumulation of knowledge, more questions arise regarding the proper approach to mutation carriers diagnosed as having cancer. Moreover, the number of questions regarding the recommended management methods for healthy carriers and the potential risk-reducing measures is increasing constantly. In this review, we discuss these issues and summarize contemporary recommendations.
AB - Although more than 15 years have elapsed since the discovery of the BRCA1 and BRCA2 genes and the associated increased risk of breast and ovarian cancers in mutation carriers, our understanding of the syndrome is still evolving. With the accumulation of knowledge, more questions arise regarding the proper approach to mutation carriers diagnosed as having cancer. Moreover, the number of questions regarding the recommended management methods for healthy carriers and the potential risk-reducing measures is increasing constantly. In this review, we discuss these issues and summarize contemporary recommendations.
KW - BRCA
KW - Counseling
KW - Healthy mutation carriers
UR - http://www.scopus.com/inward/record.url?scp=73449111656&partnerID=8YFLogxK
U2 - 10.1111/IGC.0b013e3181b33c4a
DO - 10.1111/IGC.0b013e3181b33c4a
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AN - SCOPUS:73449111656
SN - 1048-891X
VL - 19
SP - 1156
EP - 1159
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
IS - 7
ER -
