The correlation between retinal blood flow velocity measured by the retinal function imager and various physiological parameters

Zvia Burgansky-Eliash, Anat Lowenstein, Meira Neuderfer, Anat Kesler, Hila Barash, Darin A. Nelson, Amiram Grinvald, Adiel Barak

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND OBJECTIVE: The Retinal Function Imager (RFI) (Optical Imaging Ltd., Rehovot, Israel) measures retinal blood flow velocity non-invasively. The authors studied the reproducibility of these measurements and assessed the effect of physiological components on them. PATIENTS AND METHODS: Sixty-seven individuals with no retinal pathology were recruited. Velocity reproducibility was verified by comparing repeated RFI measurements. The correlation of the velocity with physiological parameters was assessed by mixed linear and Gaussian models. RESULTS: The average velocity was 4.2 ± 0.9 mm/sec arterial and 3.3 ± 0.8 mm/sec venous. Variability was 7.5% ± 3.7% and interclass correlation coefficient was r = 0.744. Venous velocity decreased after 40 years of age (0.32 mm/sec per decade, P <.01). Arterial velocity increased as mean arterial pressure increased (0.25 mm/sec per 10 mm Hg, P <.01). There was also a positive association between velocities and heart rate (arteries: 0.21 mm/sec per 10 bpm, P <.05; veins: 0.22 mm/sec per 10 bpm, P <.01). CONCLUSION: The RFI provides a reproducible, noninvasive technique to assess retinal velocities.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalOphthalmic Surgery Lasers and Imaging
Volume44
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

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