The complex epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae

Ruthy Tal Jasper; Joseph R. Coyle; David E. Katz; Dror Marchaim

doi:10.2217/fmb.15.16

The complex epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae

Ruthy Tal Jasper, Joseph R. Coyle, David E. Katz, Dror Marchaim^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Antimicrobial resistance is a growing worldwide iatrogenic complication of modern medical care. Extended-spectrum β-lactamases have emerged as one of the most successful resistance mechanisms, limiting our therapeutic options to treat various human infections. The dissemination of these enzymes to the community probably signifies an irreversible step. This paper will review the evolution of human infections associated with extended-spectrum β-lactamase-producing organisms in the past 20 years, and will present and discuss the current challenges, controversies, debates and knowledge gaps in this research field.

Original language	English
Pages (from-to)	819-839
Number of pages	21
Journal	Future Microbiology
Volume	10
Issue number	5
DOIs	https://doi.org/10.2217/fmb.15.16
State	Published - 1 May 2015

Keywords

E. coli
Gram negative
Klebsiella pneumoniae
MDROs
Proteus mirabilis
ST-131
antibiotic stewardship
carbapenem
community acquired
healthcare associated

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Antimicrobial resistance is a growing worldwide iatrogenic complication of modern medical care. Extended-spectrum β-lactamases have emerged as one of the most successful resistance mechanisms, limiting our therapeutic options to treat various human infections. The dissemination of these enzymes to the community probably signifies an irreversible step. This paper will review the evolution of human infections associated with extended-spectrum β-lactamase-producing organisms in the past 20 years, and will present and discuss the current challenges, controversies, debates and knowledge gaps in this research field.",

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AB - Antimicrobial resistance is a growing worldwide iatrogenic complication of modern medical care. Extended-spectrum β-lactamases have emerged as one of the most successful resistance mechanisms, limiting our therapeutic options to treat various human infections. The dissemination of these enzymes to the community probably signifies an irreversible step. This paper will review the evolution of human infections associated with extended-spectrum β-lactamase-producing organisms in the past 20 years, and will present and discuss the current challenges, controversies, debates and knowledge gaps in this research field.

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The complex epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae

Abstract

Keywords

UN SDGs

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