The complement system and primary biliary cirrhosis

C. Benbassat, M. Schlesinger, Y. Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Primary biliary cirrhosis (PBC) is a chronic liver disease of unknown etiology. Several immunological abnormalities found in PBC support the hypothesis that autoimmune mechanisms are involved in its pathogenesis. The complement system being an important constituent of the immune system had not been extensively studied regarding its relationship with PBC. However, some workers reported abnormally high serum levels of some complement components with the exception of C4 that was found to be low. Here we review the literature and analyze the possible roles played by the complement system in PBC.

Original languageEnglish
Pages (from-to)51-61
Number of pages11
JournalJournal of Clinical and Laboratory Immunology
Issue number2
StatePublished - 1992
Externally publishedYes


  • Autoimmunity
  • Complement
  • Immune complexes


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