The Common Immunogenic Etiology of Chronic Fatigue Syndrome: From Infections to Vaccines via Adjuvants to the ASIA Syndrome

Hemda Rosenblum, Yehuda Shoenfeld, Howard Amital

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic fatigue syndrome (CFS) is characterized by unexplained fatigue that lasts for at least 6 months with a constellation of other symptoms. Most cases start suddenly, and are usually accompanied by a flu-like illness. It is a symptom-based diagnosis of exclusion, the pathogenesis of which is unknown. Studies have examined and hypothesized about the possible biomedical and epidemiologic characteristics of the disease, including genetic predisposition, infections, endocrine abnormalities, and immune dysfunction and psychological and psychosocial factors. Recently, the AISA (autoimmune/inflammatory syndrome induced by adjuvants) syndrome was recognized, indicating the possible contribution of adjuvants and vaccines to the development of autoimmunity.

Original languageEnglish
Pages (from-to)851-863
Number of pages13
JournalInfectious Disease Clinics of North America
Volume25
Issue number4
DOIs
StatePublished - Dec 2011

Keywords

  • ASIA syndrome
  • Adjuvants
  • Autoimmunity
  • Chronic fatigue syndrome
  • Vaccinations

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